Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...
Бүрэн тодорхойлолт
Номзүйн дэлгэрэнгүй
| Үндсэн зохиолчид: |
Davies, S,
Garner, A,
Goddard, E,
Kruchinin, D,
Roberts, P,
Rodriguez-Solla, H,
Smith, A |
|---|
| Формат: | Journal article
|
|---|
| Хэл сонгох: | English |
|---|
| Хэвлэсэн: |
2006
|
|---|