Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Davies, S, Garner, A, Goddard, E, Kruchinin, D, Roberts, P, Rodriguez-Solla, H, Smith, A
التنسيق:	Journal article
اللغة:	English
منشور في:	2006

مواد مشابهة

Asymmetric synthesis of 3,4-anti- and 3,4-syn-substituted aminopyrrolidines via lithium amide conjugate addition.
حسب: Davies, S, وآخرون
منشور في: (2007)

Asymmetric synthesis of Sedum alkaloids via lithium amide conjugate addition
حسب: Davies, S, وآخرون
منشور في: (2009)

Asymmetric total synthesis of sperabillins B and D via lithium amide conjugate addition.
حسب: Davies, S, وآخرون
منشور في: (2004)

Cyclic beta-amino acid derivatives: synthesis via lithium amide promoted tandem asymmetric conjugate addition-cyclisation reactions.
حسب: Davies, S, وآخرون
منشور في: (2005)

Asymmetric synthesis of beta-substituted Baylis-Hillman products via lithium amide conjugate addition
حسب: Chernega, A, وآخرون
منشور في: (2007)

Asymmetric synthesis of 4-amino-gamma-butyrolactones via lithium amide conjugate addition
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منشور في: (2007)

Asymmetric synthesis of the cis- and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid.
حسب: Bunnage, M, وآخرون
منشور في: (2004)

Asymmetric synthesis and applications of beta-amino Weinreb amides: asymmetric synthesis of (S)-coniine.
حسب: Burke, A, وآخرون
منشور في: (2004)

Homochiral lithium amides for the asymmetric synthesis of beta-amino acids
حسب: Davies, S, وآخرون
منشور في: (2006)

Lithium amides as homochiral ammonia equivalents for conjugate additions to α β-unsaturated esters: Asymmetric synthesis of (S)-β-leucine
حسب: Davies, S, وآخرون
منشور في: (2010)

Asymmetric syntheses of dihydroxyhomoprolines via doubly diastereoselective lithium amide conjugate addition reactions
حسب: Davies, S, وآخرون
منشور في: (2013)

Conjugate addition of lithium N-phenyl-N-(α-methylbenzyl)amide: application to the asymmetric synthesis of (R)-(-)-angustureine.
حسب: Bentley, SA, وآخرون
منشور في: (2011)

Asymmetric syntheses of (+)-negamycin, (+)-3-epi-negamycin and sperabillin C via lithium amide conjugate addition
حسب: Davies, S, وآخرون
منشور في: (2011)

Conjugate addition of lithium N-tert-butyldimethylsilyloxy-N-(alpha-methylbenzyl)amide: asymmetric synthesis of beta(2,2,3)-trisubstituted amino acids
حسب: Bentley, SA, وآخرون
منشور في: (2010)

Parallel kinetic resolution of acyclic γ-amino-α,β-unsaturated esters: application to the asymmetric synthesis of 4-aminopyrrolidin-2-ones.
حسب: Davies, S, وآخرون
منشور في: (2012)

Parallel kinetic resolution of acyclic γ-amino-α,β- unsaturated esters: Application to the asymmetric synthesis of 4-aminopyrrolidin-2-ones
حسب: Davies, S, وآخرون
منشور في: (2012)

Asymmetric synthesis of beta-amino-gamma-substituted-gamma-butyrolactones: double diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters.
حسب: Cailleau, T, وآخرون
منشور في: (2007)

Enantiopure lithium amides in asymmetric synthesis
حسب: Lv, L
منشور في: (2013)

Diastereoselective conjugate reduction with samarium diiodide: asymmetric synthesis of methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate.
حسب: Davies, S, وآخرون
منشور في: (2004)

The conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents part III: 2012-2017
حسب: Davies, S, وآخرون
منشور في: (2017)

The conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents part II: 2005-2011
حسب: Davies, S, وآخرون
منشور في: (2012)

The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications
حسب: Davies, S, وآخرون
منشور في: (2005)

Doubly diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters containing cis- and trans-dioxolane units.
حسب: Davies, S, وآخرون
منشور في: (2009)

Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinones.
حسب: Davies, S, وآخرون
منشور في: (2007)

Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.
حسب: Abraham, E, وآخرون
منشور في: (2008)

Asymmetric synthesis of cyclic beta-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis
حسب: Chippindale, A, وآخرون
منشور في: (2003)

Rapid stereoselective syntheses of heteroarene-fused azacycles via diastereoselective conjugate addition of heteroaryl substituted lithium amides
حسب: Davies, S, وآخرون
منشور في: (2018)

Doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure N-enoyl oxazolidin-2-ones: a mechanistic probe
حسب: Davies, S, وآخرون
منشور في: (2010)

Double asymmetric induction as a mechanistic probe: conjugate addition for the asymmetric synthesis of a pseudotripeptide.
حسب: Davies, S, وآخرون
منشور في: (2004)

Double asymmetric induction as a mechanistic probe: conjugate addition for the asymmetric synthesis of a pseudotripeptide.
حسب: Davies, S, وآخرون
منشور في: (2004)

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral alpha-amino acids
حسب: Bull, S, وآخرون
منشور في: (2001)

Double asymmetric induction as a mechanistic probe: the doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure alpha,beta-unsaturated esters and enantiopure alpha,beta-unsaturated hydroxamates
حسب: Davies, S, وآخرون
منشور في: (2011)

Double asymmetric induction as a mechanistic probe: the doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure alpha,beta-unsaturated esters and enantiopure alpha,beta-unsaturated hydroxamates
حسب: Davies, S, وآخرون
منشور في: (2011)

Double asymmetric induction as a mechanistic probe: the doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure α,β-unsaturated esters and enantiopure α,β-unsaturated hydroxamates
حسب: Davies, S, وآخرون
منشور في: (2011)

Asymmetric conjugate reductions with samarium diiodide: asymmetric synthesis of (2S,3R)- and (2S,3S)-[2-2H,3-2H]-leucine-(S)-phenylalanine dipeptides and (2S,3R)-[2-(2)H,3-2H]-phenylalanine methyl ester.
حسب: Davies, S, وآخرون
منشور في: (2005)

ASYMMETRIC MICHAEL ADDITIONS OF HOMOCHIRAL MAGNESIUM AMIDES
حسب: Bunnage, M, وآخرون
منشور في: (1994)

Asymmetric synthesis of beta-amino acids via the Michael addition of chiral metal amides
حسب: Davies, S, وآخرون
منشور في: (1997)

A tandem conjugate addition/cyclization protocol for the asymmetric synthesis of 2-aryl-4-aminotetrahydroquinoline-3-carboxylic acid derivatives.
حسب: Davies, S, وآخرون
منشور في: (2009)

Chiral lithium amide mediated asymmetric synthesis of 3-aryl-3,4-dihydroisocoumarins
حسب: Arvind Kumar Sharma, وآخرون
منشور في: (2010-06-01)

Stereoselective synthesis of perillaldehyde-based chiral β-amino acid derivatives through conjugate addition of lithium amides
حسب: Zsolt Szakonyi, وآخرون
منشور في: (2014-11-01)