Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose.

Cell proliferation may be measured in vivo by quantifying DNA synthesis with isotopically labeled deoxyribonucleotide precursors. Deuterium-labeled glucose is one such precursor which, because it achieves high levels of enrichment for a short period, is well suited to the study of rapidly dividing c...

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Bibliographic Details
Main Authors: Macallan, D, Asquith, B, Zhang, Y, de Lara, C, Ghattas, H, Defoiche, J, Beverley, P
Format: Journal article
Language:English
Published: 2009