YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis to silence genes on a single X chromosome in XX female cells, thereby equalising levels of X-linked gene expression relative to XY males. XCI progresses over a period of several days, with some X-linked genes s...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
EMBO Press
2024
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