Two hits revisited again.

INTRODUCTION AND METHODS: Since the concept of the "two hit hypothesis" was introduced over 20 years ago, a wealth of genetic data has accumulated on the mutations found at tumour suppressor loci. Perhaps surprisingly, these data conceal large gaps in our knowledge which genetic and funct...

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Bibliographic Details
Main Authors: Tomlinson, I, Roylance, R, Houlston, R
Format: Journal article
Language:English
Published: 2001