Re-establishing immunological self-tolerance in autoimmune disease.

Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues...

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Bibliographic Details
Main Authors: Sakaguchi, S, Powrie, F, Ransohoff, R
Format: Journal article
Language:English
Published: 2012