Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer’s disease (AD). Assembled tau associates with extracellular vesicles (EVs) in the central nervous system of individuals with AD, which is linked to its clearance and...

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Bibliographic Details
Main Authors: Fowler, SL, Behr, TS, Turkes, E, O’Brien, DP, Cauhy, PM, Rawlinson, I, Edmonds, M, Foiani, MS, Schaler, A, Crowley, G, Bez, S, Ficulle, E, Tsefou, E, Fischer, R, Geary, B, Gaur, P, Miller, C, D’Acunzo, P, Levy, E, Duff, KE, Ryskeldi-Falcon, B
Format: Journal article
Language:English
Published: Nature Research 2024