Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

Ցույց տալ այլ տարբերակներ (1)

RATIONALE:: Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart,...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Lygate, C, Aksentijevic, D, Dawson, D, Ten Hove, M, Phillips, D, De Bono, J, Medway, D, Sebag-Montefiore, L, Hunyor, I, Channon, K, Clarke, K, Zervou, S, Watkins, H, Balaban, R, Neubauer, S
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2013

Նմանատիպ նյութեր

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
‌: Lygate, C, և այլն
Հրապարակվել է: (2013)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
‌: Lygate, C, և այլն
Հրապարակվել է: (2012)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
‌: Makinen, K, և այլն
Հրապարակվել է: (2008)

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
‌: Lygate, C, և այլն
Հրապարակվել է: (2011)

Creatine uptake in mouse hearts with genetically altered creatine levels.
‌: ten Hove, M, և այլն
Հրապարակվել է: (2008)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
‌: Lygate, C, և այլն
Հրապարակվել է: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
‌: Lygate, C, և այլն
Հրապարակվել է: (2012)

Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging
‌: Lygate, C, և այլն
Հրապարակվել է: (2011)

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
‌: Lygate, C, և այլն
Հրապարակվել է: (2009)

Supra-normal (phospho-)creatine levels lead to heart failure in mice overexpressing the cardiac creatine transporter - a longitudinal study
‌: ten Hove, M, և այլն
Հրապարակվել է: (2006)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
‌: Zervou, S, և այլն
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Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
‌: Faller, K, և այլն
Հրապարակվել է: (2013)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
‌: Zervou, S, և այլն
Հրապարակվել է: (2013)

Changes in creatine transporter function during cardiac maturation in the rat.
‌: Fischer, A, և այլն
Հրապարակվել է: (2010)

Complete absence of creatine but unaltered ATP levels in hearts from AGAT knockout mice
‌: ten Hove, M, և այլն
Հրապարակվել է: (2007)

Supernormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - Insights from creatine transporter over-expression transgenic mice
‌: Wallis, J, և այլն
Հրապարակվել է: (2005)

Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart
‌: Branovets, J, և այլն
Հրապարակվել է: (2013)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
‌: Ten Hove, M, և այլն
Հրապարակվել է: (2007)

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
‌: Wallis, J, և այլն
Հրապարակվել է: (2005)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
‌: Zervou, S, և այլն
Հրապարակվել է: (2010)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
‌: Lygate, C, և այլն
Հրապարակվել է: (2013)

The creatine kinase energy transport system in the failing mouse heart.
‌: Lygate, C, և այլն
Հրապարակվել է: (2007)

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
‌: Phillips, D, և այլն
Հրապարակվել է: (2010)

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
‌: Faller, K, և այլն
Հրապարակվել է: (2017)

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.
‌: Branovets, J, և այլն
Հրապարակվել է: (2013)

The creatine kinase energy transport system in the failing mouse heart
‌: Lygate, C, և այլն
Հրապարակվել է: (2006)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
‌: Aksentijević, D, և այլն
Հրապարակվել է: (2014)

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.
‌: Kiterie M E Faller, և այլն
Հրապարակվել է: (2013-01-01)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
‌: Lygate, C, և այլն
Հրապարակվել է: (2006)

Mechanisms of creatine depletion in chronically failing rat heart.
‌: Ten Hove, M, և այլն
Հրապարակվել է: (2005)

Hearts from gamt ko mice lack phospho-creatine, show reduced inotropic reserve and are more prone to ischemia
‌: ten Hove, M, և այլն
Հրապարակվել է: (2005)

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
‌: Lygate, CA, և այլն
Հրապարակվել է: (2022)

GUANIDINOACETATE N-METHYLTRANSFERASE KNOCKOUT MICE EXHIBIT NORMAL LEFT VENTRICULAR REMODELLING, HAEMODYNAMICS AND SURVIVAL AFTER MYOCARDIAL INFARCTION DESPITE LACK OF PHOSPHOCREATINE
‌: Lygate, C, և այլն
Հրապարակվել է: (2010)

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
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Հրապարակվել է: (2022-08-01)

Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period
‌: Aksentijevic, D, և այլն
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Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool
‌: Boehm, E, և այլն
Հրապարակվել է: (2002)

COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE
‌: Aksentijevic, D, և այլն
Հրապարակվել է: (2010)

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.
‌: Aksentijević, D, և այլն
Հրապարակվել է: (2010)

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine.
‌: Boehm, E, և այլն
Հրապարակվել է: (2003)

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury
‌: Cao, F, և այլն
Հրապարակվել է: (2018)