Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcɛRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-Å-resolution crystal structure of human I...

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Autors principals:	Holdom, MD, Davies, A, Nettleship, J, Bagby, S, Dhaliwal, B, Girardi, E, Hunt, J, Gould, H, Beavil, A, McDonnell, J, Owens, R, Sutton, B
Format:	Journal article
Idioma:	English
Publicat:	2011

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