Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides †

Rhodanines have been characterised as ‘difficult to progress’ compounds for medicinal use, though one rhodanine is used for diabetes mellitus treatment and others are in clinical development. Rhodanines can undergo hydrolysis to enethiols which are inhibitors of metallo-enzymes, such as metallo β-la...

Description complète

Détails bibliographiques
Auteurs principaux: Kamps, JJAG, Zhang, D, Claridge, TDW, Schofield, CJ
Format: Journal article
Langue:English
Publié: Royal Society of Chemistry 2024