Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion

Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion. Monitoring genetic markers of resistance can help to guide antimalarial ther...

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Main Authors: Imwong, M, Suwannasin, K, Srisutham, S, Vongpromek, R, Promnarate, C, Saejeng, A, Phyo, AP, Proux, S, Pongvongsa, T, Chea, N, Miotto, O, Tripura, R, Nguyen Hoang, C, Dysoley, L, Ho Dang Trung, N, Peto, TJ, Callery, JJ, van der Pluijm, RW, Amaratunga, C, Mukaka, M, von Seidlein, L, Mayxay, M, Thuy-Nhien, NT, Newton, PN, Day, NPJ, Ashley, EA, Nosten, FH, Smithuis, FM, Dhorda, M, White, NJ, Dondorp, AM
Format: Journal article
Language:English
Published: American Society for Microbiology 2021