Design and synthesis of haptens for the catalytic antibody-promoted dynamic kinetic resolution of oxazolin-5-ones

The synthesis of the first two haptens designed to elicit catalytic hydrolytic antibodies for the dynamic kinetic resolution of racemic 4-substituted 4H-oxazolin-5-ones is reported. A cyclic phosphinate and a 2,5-dihydro-1H-pyrrolium derivative were chosen as "first generation" haptens. Th...

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Bibliographic Details
Main Authors: Briot, A, Bujard, M, Gouverneur, V, Mioskowski, C
Format: Journal article
Language:English
Published: 2002