Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the hypotension seen in these conditions, vs. the...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Chuaiphichai, S, Starr, A, Nandi, M, Channon, K, McNeill, E
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Elsevier 2015

Παρόμοια τεκμήρια

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ανά: Chuaiphichai, S, κ.ά.
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ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2023)

Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2018)

Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (Angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2018)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2014)

Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo
ανά: McNeill, E, κ.ά.
Έκδοση: (2012)

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
ανά: Douglas, G, κ.ά.
Έκδοση: (2018)

The requirement for endothelial cell tetrahydrobiopterin in health and disease
ανά: Chuaiphichai, S
Έκδοση: (2014)

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
ανά: McNeill, E, κ.ά.
Έκδοση: (2012)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
ανά: Crabtree, M, κ.ά.
Έκδοση: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
ανά: Crabtree, M, κ.ά.
Έκδοση: (2011)

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
ανά: Ali, Z, κ.ά.
Έκδοση: (2013)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
ανά: Channon, K
Έκδοση: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
ανά: Channon, K
Έκδοση: (2004)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
ανά: Ali, Z, κ.ά.
Έκδοση: (2008)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
ανά: Alp, N, κ.ά.
Έκδοση: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2014)

201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin.
ανά: McNeill, E, κ.ά.
Έκδοση: (2014)

Tetrahydrobiopterin in cardiovascular health and disease.
ανά: Bendall, J, κ.ά.
Έκδοση: (2014)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
ανά: Alp, N, κ.ά.
Έκδοση: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
ανά: Khoo, J, κ.ά.
Έκδοση: (2005)

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases
ανά: Shinozaki Kazuya, κ.ά.
Έκδοση: (2006-02-01)

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
ανά: Schmidt, T, κ.ά.
Έκδοση: (2010)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
ανά: Alp, N, κ.ά.
Έκδοση: (2003)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
ανά: Chuaiphichai, S, κ.ά.
Έκδοση: (2021)

Endothelial cell tetrahydrobiopterin: going with the flow.
ανά: De Bono, J, κ.ά.
Έκδοση: (2007)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
ανά: Khoo, J, κ.ά.
Έκδοση: (2005)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
ανά: Rinze, R, κ.ά.
Έκδοση: (2008)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
ανά: Crabtree, M, κ.ά.
Έκδοση: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
ανά: Crabtree, M, κ.ά.
Έκδοση: (2011)

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
ανά: Cosentino, F, κ.ά.
Έκδοση: (2008)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
ανά: Channon, K
Έκδοση: (2004)

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
ανά: McNeill, E, κ.ά.
Έκδοση: (2015)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
ανά: Cai, S, κ.ά.
Έκδοση: (2005)

Novel role of 5-methyl-(6S)-tetrahydrofolate in mediating endothelial cell tetrahydrobiopterin in pregnancy and implications for gestational hypertension
ανά: Dickinson, Y, κ.ά.
Έκδοση: (2024)

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
ανά: Antoniades, C, κ.ά.
Έκδοση: (2011)

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
ανά: Antoniades, C, κ.ά.
Έκδοση: (2011)

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells
ανά: Shiota Kazuhiro, κ.ά.
Έκδοση: (2002-02-01)

Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration
ανά: Schmidt, T, κ.ά.
Έκδοση: (2009)