Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

<p>Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here we analyzed summary statistics from 56 complex traits (average <em>N</em> = 101,401) by extendi...

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Bibliographic Details
Main Authors: Gazal, S, Finucane, H, Furlotte, N, Loh, P, Palamara, P, Liu, X, Schoech, A, Bulik-Sullivan, B, Neale, B, Gusev, A, Price, A
Format: Journal article
Published: Springer Nature 2017