PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a negative regulator of activated T cells, is markedly upregulated on the surface of exhausted virus-specific CD8 T cells in mi...

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Bibliographic Details
Main Authors:	Day, C, Kaufmann, D, Kiepiela, P, Brown, J, Moodley, E, Reddy, S, Mackey, E, Miller, J, Leslie, A, DePierres, C, Mncube, Z, Duraiswamy, J, Zhu, B, Eichbaum, Q, Altfeld, M, Wherry, E, Coovadia, H, Goulder, P, Klenerman, P, Ahmed, R, Freeman, G, Walker, B
Format:	Journal article
Language:	English
Published:	2006

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

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