A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

The retroviral restriction factor tripartite motif-containing 5α (Trim5α) acts during the early postentry stages of the retroviral life cycle to block infection by a broad range of retroviruses, disrupting reverse transcription and integration. The mechanism of this restriction is poorly understood,...

Повний опис

Бібліографічні деталі
Автори: Keown, J, Black, M, Ferron, A, Yap, M, Barnett, M, Pearce, F, Stoye, J, Goldstone, D
Формат: Journal article
Мова:English
Опубліковано: American Society for Biochemistry and Molecular Biology 2018