A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins
The retroviral restriction factor tripartite motif-containing 5α (Trim5α) acts during the early postentry stages of the retroviral life cycle to block infection by a broad range of retroviruses, disrupting reverse transcription and integration. The mechanism of this restriction is poorly understood,...
Автори: | , , , , , , , |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
American Society for Biochemistry and Molecular Biology
2018
|