Neuroprotection achieved with a novel proteasome inhibitor which blocks NF-kappaB activation.
Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significan...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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