Coregulated human globin genes are frequently in spatial proximity when active

The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin genes and show that the gene-dense chromatin surrounding the human α-globin genes is frequently decondensed, independent of transcription....

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Bibliographic Details
Main Authors: Brown, J, Leach, J, Atzberger, A, Lee-Prudhoe, J, Wood, W, Higgs, D, Iborra, F, Buckle, V, Reittie, J
Format: Journal article
Published: Rockefeller University Press 2006