The role of mechanics in the growth and homeostasis of the intestinal crypt

We present a mechanical model of tissue homeostasis that is specialised to the intestinal crypt. Growth and deformation of the crypt, idealised as a line of cells on a substrate, are modelled using morphoelastic rod theory. Alternating between Lagrangian and Eulerian mechanical descriptions enables...

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Bibliographic Details
Main Authors: Almet, AA, Byrne, H, Maini, P, Moulton, D
Format: Journal article
Language:English
Published: Springer 2020