Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk
Bromodomain-containing proteins of the BET family recognize histone lysine acetylation and mediate transcriptional activation of target genes such as the MYC oncogene. Pharmacological inhibitors of BET domains promise therapeutic benefits in a variety of cancers. We performed a high-diversity chemic...
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Format: | Journal article |
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Nature Publishing Group
2016
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