An alkyne linchpin strategy for drug:pharmacophore conjugation: Experimental and computational realization of a meta-selective inverse sonogashira coupling
The late-stage functionalization (LSF) of pharmaceutical and agrochemical compounds by the site-selective activation of C-H bonds offers immediate access to diverse structural analogs and expands the accessible chemical space. We report a C-H functionalization LSF strategy that hinges on the use of...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2020
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