Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

2-Oxoglutarate (2OG) oxygenases have important roles in human biology and are validated medicinal chemistry targets. Improving the selectivity profile of broad-spectrum 2OG oxygenase inhibitors may help enable the identification of selective inhibitors for use in functional assignment work. We repor...

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Bibliographic Details
Main Authors: Brewitz, L, Nakashima, Y, Tumber, A, Salah, E, Schofield, CJ
Format: Journal article
Language:English
Published: Elsevier 2021