Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
Individuals with the rare developmental disorder fibrodysplasia ossificans progressiva (FOP) experience disabling heterotopic ossification caused by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2, encoded by the gene ACVR1. Small molecule BMP type I re...
| Hlavní autoři: | , |
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| Médium: | Journal article |
| Jazyk: | English |
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Elsevier
2017
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