A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves of infection. These variants, with multiple mutations in the spike protein, are thought to facilitate escape from natural and vaccine-induced immunity and often increase in affinity for ACE2....

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Main Authors: Huo, J, Dijokaite-Guraliuc, A, Liu, C, Zhou, D, Ginn, HM, Das, R, Supasa, P, Selvaraj, M, Nutalai, R, Tuekprakhon, A, Duyvesteyn, HME, Mentzer, AJ, Skelly, D, Ritter, TG, Amini, A, Bibi, S, Adele, S, Johnson, SA, Paterson, NG, Williams, MA, Hall, DR, Plowright, M, Newman, TAH, Hornsby, H, de Silva, TI, Temperton, N, Klenerman, P, Barnes, E, Dunachie, SJ, Pollard, AJ, Lambe, T, Goulder, P, OPTIC consortium, ISARIC4C consortium, Fry, EE, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR
Format: Journal article
Language:English
Published: Cell Press 2022