Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.

Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic coupling and osteoclast-mediated bone resorption. To determine how HIF might coordinate osteoclast and osteoblast function, we studied angiopoietin-like 4 (ANGPTL4), the top HIF target gene in an Illum...

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Bibliographic Details
Main Authors: Knowles, H, Cleton-Jansen, A, Korsching, E, Athanasou, N
Format: Journal article
Language:English
Published: 2010