Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes.

Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes.

Lymphoid enhancer-binding factor 1 (LEF1) is a neutrophilic granulopoiesis regulator whose absence is critical in congenital neutropenia. We have shown LEF1 downregulation in the CD34(+) cells of the majority of myelodysplastic syndromes (MDS) patients. LEF1 was the most significant differentially e...

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Bibliographic Details
Main Authors: Pellagatti, A, Marafioti, T, Paterson, J, Malcovati, L, Della Porta, MG, Jädersten, M, Pushkaran, B, George, T, Arber, D, Killick, S, Giagounidis, A, Hellström-Lindberg, E, Cazzola, M, Wainscoat, J, Boultwood, J
Format: Journal article
Language:English
Published: 2009

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