Genetic constraints and the adaptive evolution of rabies virus in nature

We used a molecular evolutionary approach to investigate the species adaptation of rabies virus in nature. A maximum likelihood analysis of selection pressures revealed that the nucleoprotein (N) and glycoprotein (G) genes of natural viral isolates were highly constrained, especially at nonsynonymou...

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Bibliographic Details
Main Authors: Holmes, E, Woelk, C, Kassis, R, Bourhy, H
Format: Journal article
Language:English
Published: Elsevier 2002
Subjects: