Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer

Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bo...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Johnston, M, Edwards, C, Bodmer, W, Maini, P, Chapman, S
التنسيق: Journal article
منشور في: 2007