Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer

Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bo...

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Detalles Bibliográficos
Autores principales: Johnston, M, Edwards, C, Bodmer, W, Maini, P, Chapman, S
Formato: Journal article
Publicado: 2007