Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.
Studies of regulation of the haematopoietic growth factor erythropoietin led to the unexpected discovery of a widespread system of direct oxygen sensing that regulates gene expression in animals. The oxygen-sensitive signal is generated by a series of non-haem Fe(II)- and 2-oxoglutarate-dependent di...
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| Format: | Journal article |
| Language: | English |
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2013
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