Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell line...

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Bibliographic Details
Main Authors: Ong, B, Willcox, N, Wordsworth, B, Beeson, D, Vincent, A, Altmann, D, Lanchbury, J, Harcourt, G, Bell, J, Newsom-Davis, J
Format: Journal article
Language:English
Published: 1991