Population pharmacokinetic model and meta-analysis of outcomes of amphotericin B deoxycholate use in adults with cryptococcal meningitis

<p>There is a limited understanding of the population pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAmB) for cryptococcal meningitis (CM). A PK study was conducted in n=42 patients receiving DAmB 1 mg/kg q24h. A 2-compartment PK model was developed. Patient w...

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Bibliographic Details
Main Authors: Stott, K, Beardsley, J, Whalley, S, Kibengo, F, Mai, N, Kolamunnage-Dona, R, Hope, W, Day, J
Format: Journal article
Published: American Society for Microbiology 2018