PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies
The carotid body is a peripheral chemoreceptor that plays a central role in mammalian oxygen homeostasis. In response to sustained hypoxia, it manifests rapid cellular proliferation and an associated increase in responsiveness to hypoxia. Understanding the cellular and molecular mechanisms underlyin...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Physiological Society
2018
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