Low affinity antibodies against collagen type II are associated with pathology in collagen-induced arthritis in mice.
The relationship between the functional affinity of antibodies against type II collagen (CII) and the development of arthritis was studied in mice with collagen-induced arthritis. The responses of DBA/1 strain mice were compared with those of mice selectively bred to produce antibodies of high funct...
Main Authors: | Staines, N, Ekong, T, Thompson, H, Isaacs, AB, Loryman, B, Major, P, Hobbs, S, Devey, M |
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Format: | Journal article |
Language: | English |
Published: |
1990
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