Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.

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Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2). Although the strongest association signal was highly significant (P < 1 × 10(-20)), its contribution to T2D ri...

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Dettagli Bibliografici
Autori principali:	Bonnefond, A, Clément, N, Fawcett, K, Yengo, L, Vaillant, E, Guillaume, J, Dechaume, A, Payne, F, Roussel, R, Czernichow, S, Hercberg, S, Hadjadj, S, Balkau, B, Marre, M, Lantieri, O, Langenberg, C, Bouatia-Naji, N, Charpentier, G, Vaxillaire, M, Rocheleau, G, Wareham, N, Sladek, R, McCarthy, M, Dina, C, Barroso, I
Natura:	Journal article
Lingua:	English
Pubblicazione:	2012

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