Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.

BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidat...

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Main Authors: Wang, M, Roussos, P, McKenzie, A, Zhou, X, Kajiwara, Y, Brennand, K, De Luca, G, Crary, J, Casaccia, P, Buxbaum, J, Ehrlich, M, Gandy, S, Goate, A, Katsel, P, Schadt, E, Haroutunian, V, Zhang, B
Format: Journal article
Language:English
Published: BioMed Central 2016