Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies.
We present a Bayesian, Markov-chain Monte Carlo method for fine-scale linkage-disequilibrium gene mapping using high-density marker maps. The method explicitly models the genealogy underlying a sample of case chromosomes in the vicinity of a putative disease locus, in contrast with the assumption of...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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