Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class of RIPK2 kinase/NOD signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold...

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Bibliographic Details
Main Authors: Suebsuwong, C, Dai, B, Pinkas, DM, Duddupudi, AL, Li, L, Bufton, JC, Schlicher, L, Gyrd-Hansen, M, Hu, M, Bullock, AN, Degterev, A, Cuny, GD
Format: Journal article
Language:English
Published: Elsevier 2020

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