Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy- α-galactosyl ceramide derivative and v...

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Bibliographic Details
Main Authors: Jervis, P, Moulis, M, Jukes, J, Ghadbane, H, Cox, L, Cerundolo, V, Besra, G
Format: Journal article
Language:English
Published: 2012