Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may carry a sufficient cost to viral replicative capacity to facilitate subsequent immune control of a now at...

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Bibliographic Details
Main Authors: Martinez-Picado, J, Prado, J, Fry, E, Pfafferott, K, Leslie, A, Chetty, S, Thobakgale, C, Honeyborne, I, Crawford, H, Matthews, P, Pillay, T, Rousseau, C, Mullins, J, Brander, C, Walker, B, Stuart, D, Kiepiela, P, Goulder, P
Format: Journal article
Language:English
Published: 2006

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