VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma

VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma

<p>Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzi...

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Main Authors: Yao, X, Tan, J, Lim, K, Koh, J, Ooi, W, Li, Z, Huang, D, Xing, M, Chan, Y, Qu, J, Tay, S, Wijaya, G, Lam, Y, Hong, J, Lee-Lim, A, Guan, P, Ng, M, He, C, Lin, J, Nandi, T, Qamra, A, Xu, C, Myint, S, Davies, J, Goh, J, Loh, G, Tan, B, Rozen, S, Yu, Q, Tan, I, Cheng, C, Li, S, Chang, K, Tan, P, Silver, D, Lezhava, A, Steger, G, Hughes, J, Teh, B
Format: Journal article
Language:English
Published: American Association for Cancer Research 2017

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