Combined 1H-detected solid-state NMR spectroscopy and electron cryotomography to study membrane proteins across resolutions in native environments

Membrane proteins remain challenging targets for structural biology, despite much effort, as their native environment is heterogeneous and complex. Most methods rely on detergents to extract membrane proteins from their native environment, but this removal can significantly alter the structure and f...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Baker, L, Sinnige, T, Schellenberger, P, De Keyzer, J, Siebert, C, Driessen, A, Baldus, M, Grünewald, K
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Cell Press 2017