Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone.

The synthesis of the enantiomers of 6-epicastanospermine and of 1,6-diepicastanospermine from the enantiomeric gulonolactones is reported and the structure of the former is established as (1S,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxyoctahydroindolizine. The inhibitory activities of the diastereomers agains...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Fleet, G, Ramsden, N, Nash, R, Fellows, L, Jacob, G, Molyneux, R, di Bello, I, Winchester, B
Format: Journal article
Sprache:English
Veröffentlicht: 1990