Some p53-binding proteins that can function as arbiters of life and death.
Four sets of p53-binding proteins are discussed in this review. These are the E2F family, the ASPP family, Y-box-binding protein YB1, and the prolyl isomerase Pin1. Each appears to play a role in the decision by p53 to induce an arrest of cell proliferation or apoptosis and they may also be independ...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1826259091838730240 |
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| author | Braithwaite, A Del Sal, G Lu, X |
| author_facet | Braithwaite, A Del Sal, G Lu, X |
| author_sort | Braithwaite, A |
| collection | OXFORD |
| description | Four sets of p53-binding proteins are discussed in this review. These are the E2F family, the ASPP family, Y-box-binding protein YB1, and the prolyl isomerase Pin1. Each appears to play a role in the decision by p53 to induce an arrest of cell proliferation or apoptosis and they may also be independent markers of cancer. Their activities appear to be linked with the cell cycle and they may also interact with each other. In this review, the properties of each protein class are discussed as well as how they affect p53 functions. A model is proposed as to how their activities might be coordinated. |
| first_indexed | 2024-03-06T18:44:23Z |
| format | Journal article |
| id | oxford-uuid:0e029249-1c16-4306-9216-314cc60cc048 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:44:23Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:0e029249-1c16-4306-9216-314cc60cc0482022-03-26T09:43:32ZSome p53-binding proteins that can function as arbiters of life and death.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0e029249-1c16-4306-9216-314cc60cc048EnglishSymplectic Elements at Oxford2006Braithwaite, ADel Sal, GLu, XFour sets of p53-binding proteins are discussed in this review. These are the E2F family, the ASPP family, Y-box-binding protein YB1, and the prolyl isomerase Pin1. Each appears to play a role in the decision by p53 to induce an arrest of cell proliferation or apoptosis and they may also be independent markers of cancer. Their activities appear to be linked with the cell cycle and they may also interact with each other. In this review, the properties of each protein class are discussed as well as how they affect p53 functions. A model is proposed as to how their activities might be coordinated. |
| spellingShingle | Braithwaite, A Del Sal, G Lu, X Some p53-binding proteins that can function as arbiters of life and death. |
| title | Some p53-binding proteins that can function as arbiters of life and death. |
| title_full | Some p53-binding proteins that can function as arbiters of life and death. |
| title_fullStr | Some p53-binding proteins that can function as arbiters of life and death. |
| title_full_unstemmed | Some p53-binding proteins that can function as arbiters of life and death. |
| title_short | Some p53-binding proteins that can function as arbiters of life and death. |
| title_sort | some p53 binding proteins that can function as arbiters of life and death |
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