Immune checkpoint modulation enhances HIV-1 antibody induction

Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development, but current vaccine strategies have yet to induce bnAbs in humans. Many bnAbs isolated from HIV-1-infected individuals are encoded by immunoglobulin gene rearrangments with infrequent...

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Bibliographic Details
Main Authors: Bradley, T, Kuraoka, M, Yeh, C-H, Ogbe, A, Borrow, P, Et al.
Format: Journal article
Language:English
Published: Springer Nature 2020