Enantiopure bicyclic piperidinones: stereoselectivity in lactam enolate alkylations.
The synthesis and alkylation of [4.3.0]-bicyclic lactams, derived from 6-oxopipecolic acid, have been investigated. Alkylation can proceed with predominantly exo-diastereoselectivity, but the efficiency of this process depends on the substitution at the hemiaminal ether system. These products can be...
| Main Authors: | , , , , , , , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
2004
|