Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells.
The CD200 receptor (CD200R) acts as a negative regulator of myeloid cells by interacting with its widely expressed ligand CD200. Using mutants expressed in U937 cells, we show that inhibition is mediated by the PTB domain binding motif (NPLY) in the receptor's cytoplasmic region. The adaptor pr...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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