Assay platform for clinically relevant metallo-β-lactamases.

Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate substrates and a set of clinically relevant MBLs. We...

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Bibliographic Details
Main Authors: van Berkel, S, Brem, J, Rydzik, A, Salimraj, R, Cain, R, Verma, A, Owens, R, Fishwick, C, Spencer, J, Schofield, C
Format: Journal article
Language:English
Published: 2013