Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
The DNA-binding protein PRDM9 directs positioning of the double strand breaks (DSBs) initiating meiotic recombination, in mice and humans. PRDM9 is the only mammalian speciation gene yet identified and is responsible for sterility phenotypes in male hybrids of certain mouse subspecies. To investigat...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Research
2016
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