Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells

<p>In prostate cancer, loss of the tumour suppressor gene,&nbsp;<em>Retinoblastoma</em>&nbsp;(<em>Rb</em>), and consequent activation of transcription factor E2F1 typically occurs at a late-stage of tumour progression. It appears to regulate a switch to an andro...

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Bibliographic Details
Main Authors: Sekar, A, Leiblich, A, Wainwright, SM, Mendes, CC, Sarma, D, Hellberg, JEEU, Gandy, C, Goberdhan, DCI, Hamdy, FC, Wilson, C
Format: Journal article
Language:English
Published: Public Library of Science 2023